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Article

Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.

The Journal of biological chemistry - 27 Sept 2013

Takahashi Maho, Dillon Tara J, Liu Chang, Kariya Yumi, Wang Zhiping, Stork Philip J S

Abstract excerpt

The small G protein Rap1 can mediate "inside-out signaling" by recruiting effectors to the plasma membrane that signal to pathways involved in cell adhesion and cell migration. This action relies on the membrane association of Rap1, which is dictated by post-translational prenylation as well as by a stretch of basic residues within its carboxyl terminus. One feature of this stretch of acidic residues is that it...

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Identifiers

PMID: 23946483
DOI: 10.1074/jbc.M113.466904
PMCID: PMC3784689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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