Article
Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation.
Journal of virology - 1 Feb 1999
Li J, Buckwold V E, Hon M W, Ou J H
Abstract excerpt
A double mutation which converts nucleotide 1765 from A to T and nucleotide 1767 from G to A is frequently found in the hepatitis B virus (HBV) genome isolated from HBV patients with chronic hepatitis symptoms. This double mutation is located in the core promoter that controls the transcription o...
Topics
- Binding Sites
- Cell Nucleus
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Hepatitis B Core Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Protein Precursors
- RNA, Viral
- Receptors, Virus
- Trans-Activators