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Article

Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins.

Journal of virology - 1 Jun 2002

Li Jie, Xu Zhenming, Zheng Yanyan, Johnson Deborah L, Ou Jing-Hsiung

Abstract excerpt

The hepatitis B virus (HBV) core promoter regulates the transcription of two related RNA products named precore RNA and core RNA. Previous studies indicate that a double-nucleotide mutation that occurs frequently during chronic HBV infection converts a nuclear receptor binding site in the core promoter to the binding site of the transcription factor hepatocyte nuclear factor-1 (HNF-1) and specifically suppresses...

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Identifiers

PMID: 12021320
DOI: 10.1128/jvi.76.12.5875-5881.2002
PMCID: PMC136206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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