Article
Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient.
The Journal of general virology - 1 Oct 2016
Nishizawa Tsutomu, Hoshino Takashi, Naganuma Atsushi, Kobayashi Tominari, Nagashima Shigeo, Takahashi Masaharu, Takagi Hitoshi, Okamoto Hiroaki
Abstract excerpt
The viral factors associated with the development of fulminant hepatitis B are not fully understood. We recently found four unique mutations [G to A at nucleotide 1742 (G1742A), C1766T, T1768A and T1809C] in the basal core promoter (BCP) region of a genotype A hepatitis B virus (HBV) strain (FH) obtained from a 53-year-old man with fatal fulminant hepatitis. To elucidate the association of the mutations of the FH...
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