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Article

Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1.

Journal of microbiology (Seoul, Korea) - 1 Oct 2022

Seong Mi So, Hwang Hyeon Jeong, Jang Eun Ah, Jang Jeong Ah, Aung Wah Wah, Kyaw Yi Yi, Cheong JaeHun

Abstract excerpt

Hepatitis B virus (HBV) infection highly increases the risk for liver cirrhosis and hepatocellular carcinoma (HCC). The clinical manifestation of HBV infection is determined by the mutual interplay of the viral genotype, host genetic factors, mode of transmission, adaptive mutations, and environmental factors. Core promoter activation plays a critical role in the pre-genomic RNA transcription of HBV for HBV...

Topics

Carcinoma, Hepatocellular
Genotype
Hepatitis B virus
Hepatitis B, Chronic
Hepatocyte Nuclear Factor 1
Humans
Liver Neoplasms
Mutation
Nucleotides
Oleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Palmitic Acid

Promoter Regions, Genetic

RNA

Transcriptional Activation

Source

Identifiers

PMID: 36167927
DOI: 10.1007/s12275-022-1675-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-36167927-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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