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Article

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.

The Journal of general virology - 1 Sept 2009

Hussain Zahid, Jung Hyeon-Sik, Ryu Dong-Kyun, Ryu Wang-Shick

Abstract excerpt

During chronic hepatitis B virus (HBV) infection, double substitution mutations in the basal core promoter (BCP) region frequently emerge that include A1762T/G1764A and the neighbouring C1766T/T1768A mutations, here termed BCP1 and BCP2, respectively. Due to a compact viral genome organization, BCP1 and BCP2 mutations result in amino acids changes in the overlapping X gene: K130M/V131I and F132Y, respectively. It...

Topics

Cell Line
Gene Expression Regulation, Viral
Hepatitis B
Hepatitis B virus
Humans
Mutation
Phenotype
Promoter Regions, Genetic
Trans-Activators
Viral Regulatory and Accessory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Identifiers

PMID: 19439550
DOI: 10.1099/vir.0.010421-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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