Article
Prevalence of mutations in core promoter/precore region in Japanese patients with chronic hepatitis B virus infection.
Digestive diseases and sciences - 1 Nov 1998
Nagasaka A, Hige S, Marutani M, Tsunematsu I, Saito M, Yamamoto Y, Konishi S, Asaka M
Abstract excerpt
We examined the frequency and significance of mutations in the core promoter and precore region in 103 Japanese patients with chronic hepatitis B virus (HBV) infection. HBV DNAs from the patients' sera were amplified by polymerase chain reaction and were directly sequenced. A double mutation (T17...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Hepatocellular
- Carrier State
- DNA, Viral
- Gene Frequency
- Hepatitis B Antibodies
- Hepatitis B e Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Japan
- Liver Cirrhosis
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic