Article
Detection of mutations in hepatitis B virus enhancer 2/core promoter and X protein regions in patients with fatal hepatitis B virus infection.
Journal of medical virology - 1 Oct 2000
Honda A, Yokosuka O, Suzuki K, Saisho H
Abstract excerpt
The enhancer 2/core promoter and the X protein regions located upstream of the precore and core regions in hepatitis B virus regulate expression of core/e antigen peptides. Mutations in the precore and core regions have been reported to be associated closely with the severity of type B hepatitis, and regions regulating expression of these peptides may also be involved in severe liver damage. Mutations were...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Child
- Enhancer Elements, Genetic
- Female
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Analysis, DNA
- Trans-Activators