Article
Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients.
Virologica Sinica - 1 Apr 2024
Li Guixin, Yang Danli, Liu Xin, Zhang Ting, Liu Hui, Zou Jun, Xu Zimeng, Chen Xiangmei, Dai Lizhong, Chen Hongsong, Lu Fengmin
Abstract excerpt
Naturally occurred precore (PC, G1896A) and/or basal core promoter (BCP, A1762T/G1764A) mutations are prevalent in chronic HBV-infected patients, especially those under HBeAg-negative status. However, the replicative capacity of HBV with PC/BCP mutations remains ambiguous. Herein, meta-analysis showed that, only under HBeAg-negative status, the serum HBV DNA load in patients with PC mutation was 7.41-fold higher...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.