Article
Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1998
Bennett B, Johnson T E
Abstract excerpt
Mouse strains congenic for individual quantitative trait loci (QTLs) conferring hypnotic sensitivity to ethanol were constructed by backcrossing genotypically selected ILS x ISS N2 individuals to either inbred Long Sleep (ILS) or inbred Short Sleep (ISS) mice. We used a novel "speed congenic" approach in which N2 mice were genotyped for markers flanking each of the five originally identified QTLs. Genotypic...
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