Article
High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2001
Ehringer M A, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson T E, Sikela J M
Abstract excerpt
Low initial response to alcohol has been shown to be among the best predictors of development of alcoholism. A similar phenotypic measure, difference in initial sensitivity to ethanol, has been used for the genetic selection of two mouse strains, the Inbred Long-Sleep (ILS) and Inbred Short-Sleep (ISS) mice, and for the subsequent identification of four quantitative trait loci (QTLs) for alcohol sensitivity. We...
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