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Article

Genome characterization of the selected long- and short-sleep mouse lines.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2016

Dowell Robin, Odell Aaron, Richmond Phillip, Malmer Daniel, Halper-Stromberg Eitan, Bennett Beth, Larson Colin, Leach Sonia, Radcliffe Richard A

Abstract excerpt

The Inbred Long- and Short-Sleep (ILS, ISS) mouse lines were selected for differences in acute ethanol sensitivity using the loss of righting response (LORR) as the selection trait. The lines show an over tenfold difference in LORR and, along with a recombinant inbred panel derived from them (the LXS), have been widely used to dissect the genetic underpinnings of acute ethanol sensitivity. Here we have sequenced...

Topics

Animals
Chromosome Mapping
Ethanol
Genome
Humans
Male
Mice
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Sleep

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27651241
DOI: 10.1007/s00335-016-9663-6
PMCID: PMC5110614

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