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Article

Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol.

Alcoholism, clinical and experimental research - 1 Feb 2002

Bennett B, Beeson M, Gordon L, Johnson T E

Abstract excerpt

BACKGROUND: We have identified four major genes or quantitative trait loci (QTLs) that determine duration of loss of righting reflex (LORR), induced by sedative doses of ethanol: Lore1, Lore2, Lore4, and Lore5. Together these genes explain more than 50% of the phenotypic variance for sensitivity to the sedative/hypnotic effects of ethanol between the Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) strains of...

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PMID: 11964553

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