Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol.

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Article

Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol.

Alcoholism, clinical and experimental research - 1 Feb 2002

Bennett B, Beeson M, Gordon L, Johnson T E

Abstract excerpt

BACKGROUND: We have identified four major genes or quantitative trait loci (QTLs) that determine duration of loss of righting reflex (LORR), induced by sedative doses of ethanol: Lore1, Lore2, Lore4, and Lore5. Together these genes explain more than 50% of the phenotypic variance for sensitivity to the sedative/hypnotic effects of ethanol between the Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) strains of...

Topics

Animals
Crosses, Genetic
Ethanol
Heterozygote
Homozygote
Hypnotics and Sedatives
Mice
Mice, Congenic
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Phenotype
Quantitative Trait, Heritable

Source

Open in PubMed

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PMID: 11964553

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