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Article

Mapping quantitative trait loci for ethanol-induced anesthesia in LSxSS recombinant inbred and F2 mice: methodology and results.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1994

Bennett B, Markel P D, Beeson M A, Gordon L G, Johnson T E

Abstract excerpt

QTL (quantitative trait locus) mapping is an exciting new technique currently being applied to many quantitative traits. We review the animal models and molecular genetic techniques of QTL mapping with particular reference to ethanol-induced anesthesia (sleep time). Sleep time is an easily obtained measure of initial sensitivity to ethanol. We are using three-stage strategy to map QTLs causing the difference in...

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PMID: 8974320

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