Article
Identification of a genetic region in mice that specifies sensitivity to propofol.
Anesthesiology - 1 Feb 1998
Simpson V J, Rikke B A, Costello J M, Corley R, Johnson T E
Abstract excerpt
BACKGROUND: Long-sleep (LS) and short-sleep (SS) mice, initially selected for differential sensitivity to ethanol, also exhibit differential sensitivity to propofol. By interbreeding LS and SS mice to obtain progeny whose chromosomes are a patchwork of the LS and SS chromosomes, the authors determined whether differential propofol sensitivity cosegregates with any particular chromosomal region(s). Such...
Topics
- Anesthetics, Intravenous
- Animals
- Chromosome Mapping
- Female
- Male
- Mice
- Mice, Inbred Strains
- Phenotype
- Propofol
- Quantitative Trait, Heritable
- Reflex
- Sleep
- Species Specificity