Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

doi:10.1038/sj.onc.1202213

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Article

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

Oncogene - 3 Dec 1998

Izawa I, Amano M, Chihara K, Yamamoto T, Kaibuchi K

Abstract excerpt

Recent evidence has strongly suggested the involvement of Rho family small guanosine triphosphatases (GTPases) in Ras-induced transformation. To further clarify the role of Rho family GTPases in Ras-induced transformation, we examined the effects of dominant active or dominant negative forms of R...

Topics

Actins
Animals
Cadherins
Cell Adhesion
Cell Cycle Proteins
Cell Line
Cell Size
Cell Transformation, Neoplastic
Cytoskeletal Proteins
Fibroblasts
GTP Phosphohydrolases
GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GTPase-Activating Proteins

Gene Expression

Genes, Dominant

Intracellular Signaling Peptides and Proteins

Lysophospholipids

Mutation

Source

Open in PubMed

Identifiers

PMID: 9879992
DOI: 10.1038/sj.onc.1202213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9879992-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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