Article
A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts.
Oncogene - 25 Mar 1999
Mayer T, Meyer M, Janning A, Schiedel A C, Barnekow A
Abstract excerpt
The organization of polymerized actin in the mammalian cell is regulated by several members of the rho family. Three rho proteins, cdc42, rac and rho act in a cascade to organize the intracellular actin cytoskeleton. Rho proteins are involved in the formation of actin stress fibers and adhesion plaques in fibroblasts. During transformation of mammalian cells by oncogenes the cytoskeleton is rearranged and stress...
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