Article
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
Cell - 2 May 1997
Rodriguez-Viciana P, Warne P H, Khwaja A, Marte B M, Pappin D, Das P, Waterfield M D, Ridley A, Downward J
Abstract excerpt
The pathways by which mammalian Ras proteins induce cortical actin rearrangement and cause cellular transformation are investigated using partial loss of function mutants of Ras and activated and inhibitory forms of various postulated target enzymes for Ras. Efficient transformation by Ras requir...
Topics
- 3T3 Cells
- Actins
- Animals
- Aorta
- COS Cells
- Cell Membrane
- Cell Size
- Chromones
- Cytoskeleton
- Endothelium, Vascular
- Enzyme Inhibitors
- Mice
- Morpholines
- Mutation
- Naphthalenes
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphotransferases (Alcohol Group Acceptor)