Article
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.
Molecular biology of the cell - 1 Nov 1997
Zhong C, Kinch M S, Burridge K
Abstract excerpt
Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic morphology with decreased cell-cell junctions but increased...
Topics
- ADP Ribose Transferases
- Actin Cytoskeleton
- Botulinum Toxins
- Breast
- Cell Adhesion
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Enzyme Inhibitors
- Epithelial Cells
- Fibroblasts
- GTP-Binding Proteins
- Genes, ras
- Humans
- Intercellular Junctions
- Mesoderm
- Myosin-Light-Chain Kinase
- Phenotype
- rhoA GTP-Binding Protein