Article
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.
Molecular biology of the cell - 1 Nov 1997
Zhong C, Kinch M S, Burridge K
Abstract excerpt
Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic morphology with decreased cell-cell junctions but increased focal adhesions and stress fibers. We have investigated whether the transformed phenotype is due to Rho activation....
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