Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase.

doi:10.1126/science.275.5304.1308

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Article

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase.

Science (New York, N.Y.) - 28 Feb 1997

Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K

Abstract excerpt

The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in fibroblasts stimulated by extracellular signals such as lysophosphatidic acid (LPA). Rho-kinase is activated by Rho and may mediate some biological effects of Rho. Microinjection...

Topics

3T3 Cells
Actins
Adenosine Triphosphate
Animals
Binding Sites
Cell Adhesion
Cell Line
DNA, Complementary
Enzyme Inhibitors
GTP Phosphohydrolases
Intracellular Signaling Peptides and Proteins
Lysophospholipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Protein Serine-Threonine Kinases

Recombinant Fusion Proteins

Staurosporine

rho-Associated Kinases

Source

Open in PubMed

Identifiers

PMID: 9036856
DOI: 10.1126/science.275.5304.1308

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9036856-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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