Article
Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.
Molecular and cellular biology - 1 Sept 1999
Osada M, Tolkacheva T, Li W, Chan T O, Tsichlis P N, Saez R, Kimmelman A C, Chan A M
Abstract excerpt
Multiple biological functions have been ascribed to the Ras-related G protein R-Ras. These include the ability to transform NIH 3T3 fibroblasts, the promotion of cell adhesion, and the regulation of apoptotic responses in hematopoietic cells. To investigate the signaling mechanisms responsible for these biological phenotypes, we compared three R-Ras effector loop mutants (S61, G63, and C66) for their relative...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Adhesion
- Cell Line
- Cell Survival
- Cell Transformation, Neoplastic
- DNA Primers
- GTP Phosphohydrolases
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Humans
- Mice