Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway.

The Journal of cell biology - 11 Dec 2000

Reuveni H, Geiger T, Geiger B, Levitzki A

Abstract excerpt

We have used the selective farnesylation inhibitor HR12 [cysteine-N(methyl)valine-N(cyclohexyl) glycine-methionine-O-methyl-ester] to study the role of oncogenic Ras in cytoskeletal reorganization in Ha-ras(V12)-transformed Rat1 cells (Rat1/ras). Application of HR12 resulted in complete restoration of the cytoskeleton and associated cell adhesions disrupted by oncogenic Ras. This included an increase in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adherens Junctions
Share to Alkyl and Aryl Transferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Farnesyltranstransferase

Share to Flavonoids

Share to JNK Mitogen-Activated Protein Kinases

Share to p38 Mitogen-Activated Protein Kinases

Share to Protein Prenylation

Source

Open in PubMed Open full text

Identifiers

PMID: 11121434
DOI: 10.1083/jcb.151.6.1179
PMCID: PMC2190591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway.PMID 11121434Read ↗

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.Semantic proximity Read ↗

Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.Semantic proximity Read ↗

Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.Semantic proximity Read ↗

Identification of HDAC4 as a target of γ-catenin that regulates the oncogenic K-Ras-mediated malignant phenotype of Rat2 cells.Semantic proximity Read ↗

Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcomaSemantic proximity Read ↗

Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin.Semantic proximity Read ↗

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.Semantic proximity Read ↗

Unfarnesylated transforming Ras mutant inhibits the Ras-signaling pathway by forming a stable Ras.Raf complex in the cytosol.Semantic proximity Read ↗

Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.Semantic proximity Read ↗

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.Semantic proximity Read ↗

Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells.Semantic proximity Read ↗

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.