Article
A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival.
Oncogene - 7 Jan 1999
Moorman J P, Luu D, Wickham J, Bobak D A, Hahn C S
Abstract excerpt
Rho family GTPases are known to be involved in cytoskeletal reorganization. We examined the possibility that these functions may be dictated by a balance of Rho family GTPase signaling. Using transient viral expression of RhoA, Rac1, Cdc42 and their mutants, as well as C3 exoenzyme, we altered cy...
Topics
- Animals
- Cell Cycle Proteins
- Cell Line
- Cell Survival
- Cricetinae
- Cytoskeleton
- Enzyme Activation
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Humans
- Jurkat Cells
- Phenotype
- Signal Transduction
- Sindbis Virus
- cdc42 GTP-Binding Protein
- rac GTP-Binding Proteins
- rhoA GTP-Binding Protein