Article
Host genes affecting survival period of chemically induced bladder cancer in mice.
Journal of cancer research and clinical oncology - 1 Jan 1998
Higashi S, Murai T, Mori S, Kamoto T, Yoshitomi M, Arakawa Y, Makino S, Fukushima S, Yoshida O, Hiai H
Abstract excerpt
Treatment of C57BL/6 J (B6) and NON male mice with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) resulted in a high incidence of bladder cancer. The mean survival period, however, differed significantly by strain: 481+/-219 days in B6 (n = 31) and 203+/-119 days in NON (n = 30) (P < 0.0001). Major...
Topics
- Animals
- Butylhydroxybutylnitrosamine
- Chromosome Mapping
- Genetic Linkage
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred Strains
- Microsatellite Repeats
- Quantitative Trait, Heritable
- Survival Analysis
- Urinary Bladder Neoplasms