Article
Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice.
Transgenic research - 1 Apr 2007
Davie Sarah A, Maglione Jeannie E, Manner Cathyryne K, Young Dmitri, Cardiff Robert D, MacLeod Carol L, Ellies Lesley G
Abstract excerpt
The ability to genetically manipulate mice has led to rapid progress in our understanding of the roles of different gene products in human disease. Transgenic mice have often been created in the FVB/NJ (FVB) strain due to its high fecundity, while gene-targeted mice have been developed in the 129/SvJ-C57Bl/6J strains due to the capacity of 129/SvJ embryonic stem cells to facilitate germline transmission....
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