Article
A mouse genetic locus with death clock and life clock features.
Mechanisms of ageing and development - 1 Feb 2001
Adams D D, Lucas W O, Williams B G, Berkeley B B, Turner K W, Schofield J C
Abstract excerpt
A senility syndrome, with weight loss and priapism, occurs in CBAT6/T6 mice, an exceptionally long-lived strain. Instead of dying at the expected time, these mice get senile weight loss and priapism and go on living. We have postulated that a mutant death clock kills the wrong neurons. Crosses with the NZW and C57BL/6 strains show causation by a single genetic locus (Priap1), with a pronounced gene dosage effect...
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