Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development

5 Nov 2009

Abstract excerpt

International guidelines allow for use of a short-term cancer bioassay (twenty-six weeks) in transgenic mice as a substitute for one of the two required long-term rodent bioassays in the preclinical safety evaluation of pharmaceuticals. The two models that have gained the widest acceptance by sponsors and regulatory authorities are the CB6F1-RasH2 mouse hemizygous for a human H-ras transgene and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to CRISPR and Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19893055
DOI: 10.1177/0192623309351718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical DevelopmentPMID 19893055Read ↗

Establishing a laboratory animal model from a transgenic animal: RasH2 mice as a model for carcinogenicity studies in regulatory science.Semantic proximity Read ↗

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.Semantic proximity Read ↗

Consideration of short-term carcinogenicity tests using transgenic mouse models.Semantic proximity Read ↗

Interlaboratory Comparison of Short-Term Carcinogenicity Studies Using CB6F1-rasH2 Transgenic MiceSemantic proximity Read ↗

Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals--practical pointers, mechanistic clues, and new questions.Semantic proximity Read ↗

The Tg rasH2 Mouse in Cancer Hazard IdentificationSemantic proximity Read ↗

Use of Transgenic Mice in Carcinogenicity Hazard AssessmentSemantic proximity Read ↗

CB6F1-rasH2 Mouse: Overview of Available DataSemantic proximity Read ↗

The role of transgenic mouse models in carcinogen identification.Semantic proximity Read ↗

Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic miceSemantic proximity Read ↗

Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.Semantic proximity Read ↗

Spontaneous tumor incidence in rasH2 mice: review of internal data and published literature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.