Article
BRCA2-null embryonic survival is prolonged on the BALB/c genetic background.
Molecular carcinogenesis - 1 Jul 2000
Bennett L M, McAllister K A, Blackshear P E, Malphurs J, Goulding G, Collins N K, Ward T, Bunch D O, Eddy E M, Davis B J, Wiseman R W
Abstract excerpt
Women who inherit mutations in the BRCA2 cancer susceptibility gene have an 85% chance of developing breast cancer. The function of the BRCA2 gene remains elusive, but there is evidence to support its role in transcriptional transactivation, tumor suppression, and the maintenance of genomic integrity. Individuals with identical BRCA2 mutations display a different distribution of cancers, suggesting that there are...
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