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Article

Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell.

Journal of cell science - 1 Aug 1998

Bailly A, Späth G, Bender V, Weiss M C

Abstract excerpt

Tagged versions of HNF4 or HNF1alpha cDNAs in expression vectors have been introduced by transient and stable transfection into three cell lines of hepatic origin that all fail to express these two liver-enriched transcription factors and hepatic functions. C2 and H5 cells are dedifferentiated rat hepatoma variants and WIF12-E cells are human fibroblast-rat hepatoma hybrids with a reduced complement of human...

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PMID: 9683635
DOI: 10.1242/jcs.111.16.2411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell.PMID 9683635Read ↗

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Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells.Semantic proximity Read ↗

Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway.Semantic proximity Read ↗

Cell phenotype, binding affinity and promoter structure modulate transactivation by HNF1 and LAP.Semantic proximity Read ↗

An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.Semantic proximity Read ↗

Genome-wide analysis of hepatic gene silencing in hepatoma cell variants.Semantic proximity Read ↗

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.Semantic proximity Read ↗

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors.Semantic proximity Read ↗

More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.Semantic proximity Read ↗

Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression.Semantic proximity Read ↗

Two members of an HNF1 homeoprotein family are expressed in human liverSemantic proximity Read ↗

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