Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.

doi:10.1128/MCB.17.11.6311

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.

Molecular and cellular biology - 1 Nov 1997

Chaya D, Fougère-Deschatrette C, Weiss M C

Abstract excerpt

Among the liver-enriched transcription factors identified to date, only expression of hepatocyte nuclear factor 4 (HNF4) and hepatocyte nuclear factor 1 (HNF1) is in strict correlation with hepatic differentiation in cultured rat hepatoma cells. Indeed, differentiated hepatoma cells that stably e...

Topics

Animals
Carcinoma, Hepatocellular
Cell Differentiation
Clone Cells
DNA-Binding Proteins
Epistasis, Genetic
Gene Expression Regulation, Developmental
Genetic Complementation Test
Genetic Variation
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatocyte Nuclear Factor 1-beta

Hepatocyte Nuclear Factor 4

Karyotyping

Liver

Nuclear Proteins

Phenotype

Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9343392
DOI: 10.1128/MCB.17.11.6311
PMCID: PMC232482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9343392-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.PMID 9343392Read ↗

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells.Semantic proximity Read ↗

Genome-wide analysis of hepatic gene silencing in hepatoma cell variants.Semantic proximity Read ↗

Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway.Semantic proximity Read ↗

Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell.Semantic proximity Read ↗

Cell phenotype, binding affinity and promoter structure modulate transactivation by HNF1 and LAP.Semantic proximity Read ↗

Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.Semantic proximity Read ↗

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.Semantic proximity Read ↗

Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors.Semantic proximity Read ↗

Adenovirus-mediated hepatocyte nuclear factor-4alpha overexpression maintains liver phenotype in cultured rat hepatocytes.Semantic proximity Read ↗

Regulation of albumin gene expression in hepatoma cells of fetal phenotype: dominant inhibition of HNF1 function and role of ubiquitous transcription factors.Semantic proximity Read ↗

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.Semantic proximity Read ↗

Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.