Article
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis.
Cell - 25 Jul 1997
Pan D, Rubin G M
Abstract excerpt
Notch and the disintegrin metalloprotease encoded by the kuzbanian (kuz) gene are both required for a lateral inhibition process during Drosophila neurogenesis. We show that a mutant KUZ protein lacking protease activity acts as a dominant-negative form in Drosophila. Expression of such a dominan...
Topics
- Animals
- Animals, Genetically Modified
- Biological Evolution
- Disintegrins
- Drosophila
- Drosophila Proteins
- Female
- Gene Deletion
- Gene Expression Regulation, Developmental
- Male
- Membrane Proteins
- Metalloendopeptidases
- Mice
- Molecular Sequence Data
- Mutagenesis
- Nervous System
- Phenotype
- Receptors, Cell Surface