The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.

doi:10.1016/j.mod.2006.03.005

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Article

The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.

Mechanisms of development - 1 May 2006

Albrecht Stefanie, Wang Shuoshuo, Holz Anne, Bergter Annette, Paululat Achim

Abstract excerpt

We have screened a collection of EMS mutagenized fly lines in order to identify genes involved in cardiogenesis. In the present work, we have studied a group of alleles exhibiting a hypertrophic heart. Our analysis revealed that the ADAM protein (A Disintegrin And Metalloprotease) Kuzbanian, which is the functional homologue of the vertebrate ADAM10, is crucial for proper heart formation. ADAMs are a family of...

Topics

Animals
Cell Differentiation
Disintegrins
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Embryonic Induction
Gene Expression Regulation, Developmental
Heart
Lymphatic System
Metalloendopeptidases
Mutation
Myocardium
Phenotype

Source

Open in PubMed

Identifiers

PMID: 16713197
DOI: 10.1016/j.mod.2006.03.005

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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