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Article

kuzbanian-mediated cleavage of Drosophila Notch.

Genes & development - 15 Jan 2002

Lieber Toby, Kidd Simon, Young Michael W

Abstract excerpt

Loss of Kuzbanian, a member of the ADAM family of metalloproteases, produces neurogenic phenotypes in Drosophila. It has been suggested that this results from a requirement for kuzbanian-mediated cleavage of the Notch ligand Delta. Using transgenic Drosophila expressing transmembrane Notch proteins, we show that kuzbanian, independent of any role in Delta processing, is required for the cleavage of Notch. We show...

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Identifiers

PMID: 11799064
DOI: 10.1101/gad.942302
PMCID: PMC155326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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