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Article

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.

Development (Cambridge, England) - 1 Dec 1997

Wen C, Metzstein M M, Greenwald I

Abstract excerpt

LIN-12/NOTCH proteins mediate cell-cell interactions that specify cell fates. Previous work suggested that sup-17 facilitates lin-12 signalling in Caenorhabditis elegans. Here, we show that sup-17 encodes a member of the ADAM family of metalloproteases. SUP-17 is highly similar to Drosophila KUZBANIAN, which functions in Drosophila neurogenesis, and the vertebrate ADAM10 protein. Furthermore, we show by genetic...

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Identifiers

PMID: 9428412
DOI: 10.1242/dev.124.23.4759

Genes

ADAM10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.PMID 9428412Read ↗

Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.Semantic proximity Read ↗

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MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.Semantic proximity Read ↗

The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.Semantic proximity Read ↗

Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans.Semantic proximity Read ↗

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The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.Semantic proximity Read ↗

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