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Article

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs.

Development (Cambridge, England) - 1 Dec 1997

Sotillos S, Roch F, Campuzano S

Abstract excerpt

The Notch transmembrane protein is the receptor of an evolutionary conserved pathway that mediates intercellular signalling leading to the specification of different cell types during development. In this pathway, many aspects of the signal transduction mechanism remain poorly understood, especially the role of proteolytic processing of Notch. We present genetic evidence indicating that the...

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PMID: 9428413
DOI: 10.1242/dev.124.23.4769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs.PMID 9428413Read ↗

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis.Semantic proximity Read ↗

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KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.Semantic proximity Read ↗

The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.Semantic proximity Read ↗

Unidirectional Notch signaling depends on continuous cleavage of Delta.Semantic proximity Read ↗

Spatially localized Kuzbanian required for specific activation of Notch during border cell migration.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

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SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.Semantic proximity Read ↗

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