Article
Unidirectional Notch signaling depends on continuous cleavage of Delta.
Development (Cambridge, England) - 1 Jan 2005
Sapir Amir, Assa-Kunik Efrat, Tsruya Rachel, Schejter Eyal, Shilo Ben-Zion
Abstract excerpt
Unidirectional signaling from cells expressing Delta (Dl) to cells expressing Notch is a key feature of many developmental processes. We demonstrate that the Drosophila ADAM metalloprotease Kuzbanian-like (Kul) plays a key role in promoting this asymmetry. Kul cleaves Dl efficiently both in cell culture and in flies, and has previously been shown not to be necessary for Notch processing during signaling. In the...
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