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cDNA Cloning, Expression, and Mutagenesis Study of Liver-type Prostaglandin F Synthase

1 Jan 1999

Abstract excerpt

Prostaglandin (PG) F synthase catalyzes the reduction of PGD2 to 9alpha,11beta-PGF2 and that of PGH2 to PGF2alpha on the same molecule. PGF synthase has at least two isoforms, the lung-type enzyme (Km value of 120 microM for PGD2 (Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O. (1985) J. Biol. Chem. 260, 7035-7041) and the liver-type one (Km value of 10 microM for PGD2 (Chen, L. -Y., Watanabe, K., and...

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PMID: 9867836
DOI: 10.1074/jbc.274.1.241

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