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Article

Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases.

The Journal of biological chemistry - 15 Jul 2005

Kilunga Kubata Bruno, Inoue Tsuyoshi, Okano Yousuke, Kabututu Zakayi, Martin Samuel K, Lazarus Michael, Duszenko Michael, Sumii Yuichi, Kusakari Yukiko, Matsumura Hiroyoshi, Kai Yasushi, Sugiyama Shigeru, Inaka Kouji, Inui Takashi, Urade Yoshihiro

Abstract excerpt

Trypanosoma brucei prostaglandin F2alpha synthase is an aldo-ketoreductase that catalyzes the reduction of prostaglandin H2 to PGF2alpha in addition to that of 9,10-phenanthrenequinone. We report the crystal structure of TbPGFS.NADP+.citrate at 2.1 angstroms resolution. TbPGFS adopts a parallel (alpha/beta)8-barrel fold lacking the protrudent loops and possesses a hydrophobic core active site that contains a...

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PMID: 15845552
DOI: 10.1074/jbc.M413884200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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