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Article

Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis.

Bioorganic & medicinal chemistry - 15 May 2006

Huang Xiaoqin, Yan Weili, Gao Daquan, Tong Min, Tai Hsin-Hsiung, Zhan Chang-Guo

Abstract excerpt

Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) has recently been recognized as a novel, promising drug target for inflammation-related diseases. Functional and pathological studies on this enzyme further stimulate to understand its structure and the structure-function relationships. Using an approach of the combined structure prediction, molecular docking, site-directed mutagenesis, and enzymatic activity...

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PMID: 16439136
DOI: 10.1016/j.bmc.2006.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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