Article
Guinea pig or rabbit lung flavin-containing monooxygenases with distinct mobilities in SDS-PAGE are allelic variants that differ at only two positions.
Pharmacogenetics - 1 Oct 1992
Nikbakht K N, Lawton M P, Philpot R M
Abstract excerpt
Both guinea pig and rabbit express two variants of the 'lung' flavin-containing monooxygenase (FMO), observed as three distinct phenotypes based on mobility differences in SDS-PAGE. Samples of messenger RNA prepared from lungs of the two homozygous phenotypes of the guinea pig were used for the construction of two cDNA libraries. The libraries were screened with a cDNA encoding the rabbit lung FMO, and positive...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Guinea Pigs
- Immunoblotting
- Lung
- Male
