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Article

Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2010

Zhou Yangyan, Shaw Neil, Li Yang, Zhao Yu, Zhang Rongguang, Liu Zhi-Jie

Abstract excerpt

Human prostaglandin D synthase (L-PGDS) is a lipocalin-type enzyme involved in the metabolism of arachidonic acid and plays a key role in the regulation of sleep, allergy, pain sensation, and the development of male reproductive organs. Here, using a combination of crystallographic, biochemical, mutagenesis, and kinetic studies, we have gained insights into the mode of ligand binding by human L-PGDS and have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20667974
DOI: 10.1096/fj.10-164863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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