Article
Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Russo C, Angelini G, Dapino D, Piccini A, Piombo G, Schettini G, Chen S, Teller J K, Zaccheo D, Gambetti P, Tabaton M
Abstract excerpt
We have characterized the interaction between apolipoprotein E (apoE) and amyloid beta peptide (Abeta) in the soluble fraction of the cerebral cortex of Alzheimer's disease (AD) and control subjects. Western blot analysis with specific antibodies identified in both groups a complex composed of th...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Antibodies, Monoclonal
- Apolipoproteins E
- Blotting, Western
- Brain
- Cerebral Cortex
- Epitopes
- Genotype
- Humans
- Reference Values
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization