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Article

APOE-amyloid interaction: Therapeutic targets.

Neurobiology of disease - 1 May 2020

Wisniewski Thomas, Drummond Eleanor

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that is growing in prevalence globally. It is the only major cause of death without any effective pharmacological means to treat or slow progression. Inheritance of the ε4 allele of the Apolipoprotein (APO) E gene is the strongest genetic risk factor for late-onset AD. The interaction between APOE and amyloid β (Aβ) plays a key role in AD...

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Identifiers

PMID: 32027932
DOI: 10.1016/j.nbd.2020.104784
PMCID: PMC7118587

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