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Article

Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.

Molecular and cellular biology - 1 Jan 1999

Lybarger S, Beickman K, Brown V, Dembla-Rajpal N, Morey K, Seipelt R, Rymond B C

Abstract excerpt

U4 snRNA release from the spliceosome occurs through an essential but ill-defined Prp38p-dependent step. Here we report the results of a dosage suppressor screen to identify genes that contribute to PRP38 function. Elevated expression of a previously uncharacterized gene, SPP381, efficiently suppresses the growth and splicing defects of a temperature-sensitive (Ts) mutant prp38-1. This suppression is specific in...

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Identifiers

PMID: 9858581
DOI: 10.1128/MCB.19.1.577
PMCID: PMC83915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.PMID 9858581Read ↗

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