Article
Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.
Molecular and cellular biology - 1 Jan 1999
Lybarger S, Beickman K, Brown V, Dembla-Rajpal N, Morey K, Seipelt R, Rymond B C
Abstract excerpt
U4 snRNA release from the spliceosome occurs through an essential but ill-defined Prp38p-dependent step. Here we report the results of a dosage suppressor screen to identify genes that contribute to PRP38 function. Elevated expression of a previously uncharacterized gene, SPP381, efficiently supp...
Topics
- Amino Acid Sequence
- Fungal Proteins
- Gene Expression Regulation
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- RNA Precursors
- RNA Splicing
- RNA Splicing Factors
- Repressor Proteins
- Ribonucleoproteins, Small Nuclear
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins