Article
The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing.
Genetics - 1 Jan 2004
Murphy Mark W, Olson Brian L, Siliciano Paul G
Abstract excerpt
To investigate the function of the essential U1 snRNP protein Prp40p, we performed a synthetic lethal screen in Saccharomyces cerevisiae. Using an allele of PRP40 that deletes 47 internal residues and causes only a slight growth defect, we identified aphenotypic mutations in three distinct complementation groups that conferred synthetic lethality. The synthetic phenotypes caused by these mutations were suppressed...
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