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Article

Inhibition of a spliceosome turnover pathway suppresses splicing defects.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2006

Pandit Shatakshi, Lynn Bert, Rymond Brian C

Abstract excerpt

Defects in assembly are suggested to signal the dissociation of faulty splicing complexes. A yeast genetic screen was performed to identify components of the putative discard pathway. Weak mutant alleles of SPP382 (also called NTR1) were found to suppress defects in two proteins required for spliceosome activation, Prp38p and Prp8p. Spp382p is shown necessary for cellular splicing, with premRNA and, for some...

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Identifiers

PMID: 16945917
DOI: 10.1073/pnas.0603188103
PMCID: PMC1564266

Genes

AAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of a spliceosome turnover pathway suppresses splicing defects.PMID 16945917Read ↗

The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.Semantic proximity Read ↗

A Genetic Screen Identifies PRP18a, a Putative Second Step Splicing Factor Important for Alternative Splicing and a Normal Phenotype in Arabidopsis thaliana.Semantic proximity Read ↗

Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.Semantic proximity Read ↗

Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Semantic proximity Read ↗

A dominant negative mutation in the conserved RNA helicase motif 'SAT' causes splicing factor PRP2 to stall in spliceosomes.Semantic proximity Read ↗

Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.Semantic proximity Read ↗

Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly.Semantic proximity Read ↗

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PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.Semantic proximity Read ↗

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Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.Semantic proximity Read ↗

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.Semantic proximity Read ↗

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