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Article

PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.

Molecular and cellular biology - 1 Sept 1992

Blanton S, Srinivasan A, Rymond B C

Abstract excerpt

An essential pre-mRNA splicing factor, the product of the PRP38 gene, has been genetically identified in a screen of temperature-sensitive mutants of Saccharomyces cerevisiae. Shifting temperature-sensitive prp38 cultures from 23 to 37 degrees C prevents the first cleavage-ligation event in the e...

Topics

Amino Acid Sequence
Base Sequence
DNA, Fungal
Fungal Proteins
Genes, Lethal
Hot Temperature
Kinetics
Molecular Sequence Data
Mutation
RNA Precursors
RNA Splicing
RNA Splicing Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Fungal

RNA, Small Nuclear

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1508195
DOI: 10.1128/mcb.12.9.3939-3947.1992
PMCID: PMC360275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1508195-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.PMID 1508195Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.Semantic proximity Read ↗

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.Semantic proximity Read ↗

Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Semantic proximity Read ↗

An extragenic suppressor of prp24-1 defines genetic interaction between PRP24 and PRP21 gene products of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.Semantic proximity Read ↗

Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression.Semantic proximity Read ↗

Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.Semantic proximity Read ↗

The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Semantic proximity Read ↗

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.Semantic proximity Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

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