Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.

Genetics - 1 Aug 2000

Kuhn A N, Brow D A

Abstract excerpt

The highly conserved splicing factor Prp8 has been implicated in multiple stages of the splicing reaction. However, assignment of a specific function to any part of the 280-kD U5 snRNP protein has been difficult, in part because Prp8 lacks recognizable functional or structural motifs. We have used a large-scale screen for Saccharomyces cerevisiae PRP8 alleles that suppress the cold sensitivity caused by U4-cs1, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eukaryotic Initiation Factor-4E
Share to Peptide Initiation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ribonucleoprotein, U1 Small Nuclear

Share to Ribonucleoprotein, U4-U6 Small Nuclear

Share to Ribonucleoprotein, U5 Small Nuclear

Share to Ribonucleoproteins, Small Nuclear

Share to RNA, Small Nuclear

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 10924465
DOI: 10.1093/genetics/155.4.1667
PMCID: PMC1461211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.PMID 10924465Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.Semantic proximity Read ↗

The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.Semantic proximity Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.Semantic proximity Read ↗

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.Semantic proximity Read ↗

An extragenic suppressor of prp24-1 defines genetic interaction between PRP24 and PRP21 gene products of Saccharomyces cerevisiae.Semantic proximity Read ↗

PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.Semantic proximity Read ↗

Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.Semantic proximity Read ↗

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.Semantic proximity Read ↗

Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.