Article
The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.
The Journal of biological chemistry - 30 Dec 2016
Vijaykrishna Nagampalli, Melangath Geetha, Kumar Rakesh, Khandelia Piyush, Bawa Pushpinder, Varadarajan Raghavan, Vijayraghavan Usha
Abstract excerpt
The fission yeast genome, which contains numerous short introns, is an apt model for studies on fungal splicing mechanisms and splicing by intron definition. Here we perform a domain analysis of the evolutionarily conserved Schizosaccharomyces pombe pre-mRNA-processing factor, SpPrp18. Our mutational and biophysical analyses of the C-terminal α-helical bundle reveal critical roles for the conserved region as well...
Topics
- Cell Cycle
- Crystallography, X-Ray
- Introns
- Models, Molecular
- Mutation
- Protein Conformation
- RNA Precursors
- RNA Splicing
- RNA, Fungal
- Schizosaccharomyces