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Article

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.

Nature - 21 Feb 1991

Jamieson D J, Rahe B, Pringle J, Beggs J D

Abstract excerpt

Five small nuclear RNAs (snRNAs) are required for nuclear pre-messenger RNA splicing: U1, U2, U4, U5 and U6. The yeast U1 and U2 snRNAs base-pair to the 5' splice site and branch-point sequences of introns respectively. The role of the U5 and U4/U6 small nuclear ribonucleoprotein particles (snRNPs) in splicing is not clear, though a catalytic role for the U6 snRNA has been proposed. Less is known about yeast...

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PMID: 1996139
DOI: 10.1038/349715a0

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A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.PMID 1996139Read ↗

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Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.Semantic proximity Read ↗

Structural elucidation of a PRP8 core domain from the heart of the spliceosome.Semantic proximity Read ↗

prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast.Semantic proximity Read ↗

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The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex.Semantic proximity Read ↗

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