A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.

doi:10.1038/349715a0

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Article

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.

Nature - 21 Feb 1991

Jamieson D J, Rahe B, Pringle J, Beggs J D

Abstract excerpt

Five small nuclear RNAs (snRNAs) are required for nuclear pre-messenger RNA splicing: U1, U2, U4, U5 and U6. The yeast U1 and U2 snRNAs base-pair to the 5' splice site and branch-point sequences of introns respectively. The role of the U5 and U4/U6 small nuclear ribonucleoprotein particles (snRNP...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Animals
Base Sequence
Genes, Fungal
Genes, Suppressor
Genetic Complementation Test
Genetic Linkage
Mice
Molecular Sequence Data
Mutation
Phenotype
RNA Helicases
RNA Nucleotidyltransferases
RNA Precursors
RNA Splicing
RNA, Fungal
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 1996139
DOI: 10.1038/349715a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1996139-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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